Distribution of 1-hexylcarbamoyl-5-fluorouracil and 5-fluorouracil by oral administration in mice.
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منابع مشابه
Effect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals
Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
متن کاملTopical Tretinoin and 5-Fluorouracil in treatment of epidermal nevus
Background: Epidermal nevus is a common skin hamartoma. Its definite treatment is difficult and in most cases the disease has recurrence. Objective: Evaluation of topical tretinoin 0.05% and 5 Fluorouracil (5FU) 5% in the treatment of epidermal nevus. Patients and Methods: Fifteen patients with epidermal nevus referred to skin clinic in Razi Hospital in Tehran whose diagnoses were confirm...
متن کامل5-Fluorouracil concentrations in human plasma following R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) administration.
Following administration of i.v. doses of fl,S-1 -(tetrahydro-2furanyl)-5-fluorouracil in cancer patients, discrepant results have been obtained by several investigators when assaying for 5-fluorouracil (FUra) plasma concentrations, ranging from 0.1 to 5 fig/ml at peak concentrations. The newly isolated fl,S-1(tetrahydro-2-furanyl)-5-fluorouracil metabolites with altered tetrahydrofuran moiety ...
متن کاملEffect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals
Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
متن کاملComparison of 5-fluorouracil pharmacokinetics in patients receiving continuous 5-fluorouracil infusion and oral uracil plus N1-(2'-tetrahydrofuryl)-5-fluorouracil.
Plasma 5-fluorouracil (5-FU) levels were compared in the same patients after approximately equimolar doses (1.9 mmol/ m2/day) of 5-day continuous i.v. infusion of 5-FU (CIFU) and oral administration of a formulation of two combined pharmacological agents, uracil (U) plus N1-(2'-tetrahydrofuryl)-5-fluorouracil (ftorafur or FT), a prodrug of 5-FU. Ten patients received CIFU for 5 days, then, afte...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1979
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.2.5